This year the retreat of the institute will take place from 23.05. – 24.05.2019 at the Gutshaus Parin in Parin approximately 1-hour drive away from Lübeck.
This 1,5-day meeting is dedicated to science and fun – we hope for interesting discussions, new research ideas and team spirit.
The agenda of the meeting will be posted in March 2019.
Please stay tuned if you are interested in our work.
Prof. Dr. Inke R. König, Prof. Dr. Jeanette Erdmann, and Prof. Dr. Lars Bertram from our university are among the top 1% most cited scientists of 2018 for the first time.
The criterion of frequent citation of one’s own publications in the publications of other scientists is regarded as a benchmark for the rank of the respective research achievement.
With their inclusion in the “Highly Cited Researcher” list, the three UzL professors are honoured for their publication activities between 2006 and 2016 in the newly created “Cross-Field” category.
The “Highly Cited Researchers” list is an annual list of scientists and scholars who have been recognized for their outstanding publication work. Only publications in journals listed in the “Web of Science Core Collection” (currently comprising over 20,000 international journals) are taken into account. From the publications of these journals, the top 1% measured by citations in other publications in the respective scientific field and year were then taken into account for papers published between 2006 and 2016.
The list of “Highly Cited Researchers” compiled for 2018 contains the names of approximately 6000 researchers worldwide who meet these criteria, including for the first time the three professors working at the UzL.
The statistics are based on the “Web of Sci-ence” database maintained by the US-based company Clarivate Analytics, which also calculates the “Journal Impact Factor” and publishes it annually (Source URL: https://hcr.clarivate.com/methodology/purpose-and-methodology/; under this link you will also find further details on the survey and evaluation methods).
Is Germany losing the international lead in genome sequencing and genetic diagnosis of previously unknown causes of disease? In Germany, around 30,000 children and their parents would be able to completely decipher their genetic material each year. In this way, it would be possible to track down unexplained diseases and advance the molecular understanding of diseases. This figure is calculated from around 760,000 newborns per year and an assumed frequency of up to four percent for developmental disorders caused by individual gene defects that could be investigated for their cause using whole genome sequencing (WGS).
The costs of deciphering the human genome in this way are falling rapidly worldwide. Huge databases with known mutations in 4,000 of the estimated 20,000 human genes are being created. In experienced clinical centers, “whole genome sequencing” (WGS) allows molecular diagnoses in about half of the cases studied, especially for such monogenic hereditary diseases. Other countries are leading the way: The National Health Service (NHS) of the United Kingdom has decided to introduce this complete decoding of the genetic material nationwide from October 2018 as part of routine genetic diagnostics for the clarification of certain diseases. Complete genome sequencing is to be used in intensive care units for newborns and children without a clear diagnosis, in addition to certain types of cancer. Other leading industrial countries such as France, the USA and China are moving in the same direction with their genome medicine programmes and are making rapid progress.
With the press briefing on the WISSENSWERTE renowned human geneticists present concepts for a course change for Germany. How can genome medicine in this country develop further in order to find an international connection? Why would it make sense to completely decipher the genome of newborns and children with developmental disorders? What about the “Polygenic Risk Scores”, which allegedly allow predictions to be made about individual risks for complex widespread diseases? Which strategy for genome sequencing in medicine would be the most sensible for Germany?
These questions – and yours! – will be answered by the experts on the podium.
You can watch the entire discussion on Youtube.
REFERENT*INNEN:
Prof. Dr. Michael Krawczak
Direktor des Instituts für Medizinische Informatik und Statistik
Christian-Albrechts-Universität zu Kiel
Prof. Dr. Jeanette Erdmann
Direktorin des Instituts für Kardiogenetik
Universität zu Lübeck
Prof. Dr. Olaf Rieß
Ärztlicher Direktor des Instituts für Medizinische Genomik und Angewandte Genomik
Universitätsklinikum Tübingen
Prof. Dr. Hans-Hilger Ropers
emeritierter Direktor am Max-Planck-Institut für molekulare Genetik Berlin und Professor
und Facharzt am Institut für Humangenetik, Universität Mainz
MODERATION:
Volker Stollorz
Redaktionsleiter Science Media Center Germany, Köln
Translated from the German website.
Welcome to the “Tag der Deutschen Zentren der Gesundheitsforschung” at the University of Lübeck which will be held on November 30, 2018 from 15:00 to 20:00 in the foyer of the CBBM.
This event is meant to foster collaborations among the 4 centers and to discuss potential joint future research agendas. We are happy to welcome Prof. Dr. med. Otmar Wiestler, president of the Helmholtz-Gemeinschaft, as a key note speaker. Furthermore, 4 talks will introduce the research agendas of the DZHK, DZIF, DZL, and DZD. A panel discussion with our president (Prof. Gillessen-Kaesbach) and 4 representatives of the local centers will complement the afternoon. Later, we will offer the stage to our junior scientists. Flash-Talks and poster presentations will hopefully stimulate the scientific discussions.
Full agenda and registration form can be found at www.tag-der-dzg.de
The current issue of the European Heart Journal publishes a short feature about Jeanette Erdmann´s personal story.
The link to the article can be found here.
Welcome to the 6th DZHK Retreat and 5th Young DZHK Retreat
12-15 September, 2018 in KTC Königstein (Taunus)
From 24. – 25. May 2018 our 3rd retreat will take place at the Buschhof-Kattendorf.
We will have two days of interesting science and a lot of fun.
Please register for the Cluster Symposium 2018 at http://symposium-iai.org/index.html
Genome-wide association (GWA) studies, as a prototype of large-scale OMICs studies, have advanced our understanding of the genetic basis of many common diseases. With respect to coronary artery disease (CAD) and cardiovascular risk factors, like lipids, blood pressure or BMI, they have identified hundreds of chromosomal loci that modulate disease risk. Despite their scientific success, GWA studies have been criticized for having failed so far in delivering diagnostically or therapeutically relevant products. However, the ability to achieve such goals has been strengthened recently by further layers of OMICs-based data, including large-scale transcriptomics data, and better annotation of regulatory sequences and epigenetic changes in the genome (e.g. through the ENCODE project), as well as novel tools for bioinformatics analysis, allowing a systems medicine based approach to be applied. All in all, the last decade with its “gold rush of genomic discovery” led to the identification of known and novel pathways involved in the pathogenesis of cardiovascular diseases and point to novel treatment targets.
Here, the aim of this Research Topic is to gather contributions from scientists working in the field of cardiovascular genetics who have common interests in understanding the pathomechanisms linking genetic association findings and disease to finally translate the findings from large-scale genetic studies into novel treatment options. Articles can be original research, reviews, or mini reviews.
Submissions are very welcome. Please follow the link.
Looking back – Looking forward
One-day symposium organized by Inke R. König and Jeanette Erdmann
When: Friday, January 12th, 2018 from 9:00-19:00
Where: Europäisches Hansemuseum, An der Untertrave 1, 23552 Lübeck
Confirmed Speakers: Heribert Schunkert, Munich; Bertram Müller-Myhsok, Munich; Winfried März, Mannheim; Markus M. Nöthen, Bonn; Wolfgang Lieb, Kiel; Johan Bjoerkegren, New York; Tanja Zeller, Hamburg; Andre Franke, Kiel; Thomas Meitinger, Munich; Gerard Pasterkamp, Utrecht; Manuel Mayr, London; Lars Bertram, Lübeck; Folkert Asselbergs, Utrecht; Anke Hinney, Essen & Panos Deloukas, London
This event is accrediated by the Ärztekammer Schleswig-Holstein with 10 Continuing Medical Education (CME) points.
The agenda and online registration can be found here.
