There is an urgent need to progress beyond current state-of-the-art genetics by adding further levels of -omics data and approaches that include markers of regulatory function. By integrating bioinformatical, epidemiological, clinical and experimental data, we propose to elucidate the functional basis of already-known genetic loci, as well as identify novel pathways to further understand the pathomechanisms leading to these life-threatening diseases. To fulfill these overarching goals the Institute hosts an interdisciplinary as well as international research team of 30 scientists, PhD and MD students and technicians.

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