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PhD defense at ICG

On October 6th, 2020 at 9:00 am Anja Trillhaase will defend her PhD thesis “Impact of the CAD risk locus 9p21 on vascular calcification – development of an iPSC-based model”.
We are looking forward to a great talk, vivid discussions, and an impressive Q&A session.

Of mice and men and zebrafishes. A promised land of discoveries for hypertension researchers.

An editorial commentary on our article titled “Studies in zebrafish demonstrate that CNNM2 and NT5C2 are most likely the causal genes at the blood pressure-associated locus on human chromosome 10q24.32” has been reviewed and accepted for publication in Frontiers in Cardiovascular Medicine.

The title of this Editorial is “Of mice and men and zebrafishes. A promised land of discoveries for hypertension researchers” and states that, zebrafishes are going to be the tale for hypertension research in the immediate future. 

We are grateful to the authors (Daniela Sorriento and Guido Iaccarino) for their very positive evaluation of our article.

The Editorial can be found here.

The Macrophage Migration Inhibitory Factor (MIF) promoter polymorphisms (rs3063368, rs755622) predict acute kidney injury and death after cardiac surgery

Averdunk L, Bernhagen J, Fehnle K, Surowy H, Lüdecke HJ, Mucha S, Meybohm P, Wieczorek D, Leng L, Marx G, Leaf DE, Zarbock A, Zacharowski K, On Behalf Of The RIPHeart Study Collaborators, Bucala R, Stoppe C.

J Clin Med. 2020 Sep 11;9(9):E2936. doi: 10.3390/jcm9092936.

https://pubmed.ncbi.nlm.nih.gov/32932965/

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

Nomura A, Emdin CA, Won HH, Peloso GM, Natarajan P, Ardissino D, Danesh J, Schunkert H, Correa A, Bown MJ, Samani NJ, Erdmann J, McPherson R, Watkins H, Saleheen D, Elosua R, Kawashiri MA, Tada H, Gupta N, Shah SH, Rader DJ, Gabriel S, Khera AV, Kathiresan S.

Circ Genom Precis Med. 2020 Aug 30. doi: 10.1161/CIRCGEN.119.002871.

https://pubmed.ncbi.nlm.nih.gov/32862661/

Bildschirmfoto 2020 08 28 um 19.42.30

Cardiometabolism Virtual Seminar

On Friday, September 4th, 2020 from 6:00 – 7:00 pm, Jeanette Erdmann and Thorsten Kessler (DHM, Munich) will talk about cardiovascular genetics at the “Cardiometabolism Virtual Seminar”. Please join us using Zoom ID 692-600-595.

Jeanette Erdmann, Cardiovascular genetics: Past, Present, Future
Thorsten Kessler, Insights from the GUCY1A1 coronary artery disease locus

Bildschirmfoto 2020 08 20 um 19.52.07

ColVI-CMD research at the ICG will be funded by CureCMD

The ICG is happy to announce, that Jeanette Erdmann and Franziska Haarich are amongst the recipients of Cure CMD´s 2020 Grant Awards. According to the CureCMD press release “Grants have been awarded in five subtypes: Dystroglycanopathy, Collagen VI, LAMA2, LMNA, and SELENON (SEPN1). The projects range from a study in mouse models, to new projects in gene therapy, to an extended grant focused on genetic modifiers.”

“The process was extremely competitive this year,” says Cure CMD’s Scientific Director, Dr. Gustavo Dziewczapolski. “In previous cycles we have had perhaps a dozen applicants. This year, we received a record-breaking 30 applications, which is thrilling because it indicates an expanded interest in CMD research — something we at Cure CMD have continued to cultivate over the last decade.”

The study by J. Erdmann and F. Haarich entitled: First steps towards an RNA-based therapy for COL6-MD using CRISPR interference will evaluate the unique characteristics of the gene copy (allele) carrying some of the more common Collagen VI dominant mutations, in order to target and inhibit the mutant allele and spare the unaffected allele. The team will evaluate a novel treatment strategy, called CRISPR interference (CRISPRi), to achieve suppression of the faulty gene. CRISPRi is a type of CRISPR technology, which may be safer by acting on RNA rather than directly on DNA.

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