Dr. rer. nat. Olga Schweigert

Investigating cardiovascular disease mechanisms by integrating molecular biology, cell-based systems and experimental mouse models, with the aim to develop translational approaches targeting clinical relevance and therapeutic innovation. Focusing on the following areas:

• Cardiovascular pathophysiology: hypertension, endothelial dysfunction, vascular remodeling
• Atherosclerosis and coronary artery disease (CAD): mechanisms of plaque formation and progression
• Inflammation in cardiovascular disease: immune-mediated contributions to disease development and modulation/resolution

Current Postion

01/2025 – present

Senior Postdoctoral Researcher, University of Lübeck, Institut for Cardiogenetik

01/2020 – 12/ 2024

Senior Postdoctoral Researcher, Center of Cardiovascular Science, University Medical Centre Hamburg-Eppendorf, Hamburg

03/2017 – 12/2019

Postdoctoral Researcher, University Heart Center Hamburg GmbH Department of General and Interventional Cardiology, Hamburg

08/2009 – 09/2013

Research Assistant, Institute of Biochemistry at the University of Kiel SFB 654 „Plasticity and Sleep” & SFB 877 „Protein Cleavage for Regulation

Education

08/2009 – 08/2014

Ph.D, Institute of Biochemistry at the University of Kiel;Thesis: “Molecular principles of proteolytic cleavage of Tim-1 and Tim-4 by ADAM proteases”

09/2003 – 10/2008

Diplom-Biol., (eq. M.Sc.) Carl von Ossietzky University, Oldenburg, Diploma thesis at the Institute of Humangenetik, University Bremen

Career breaks

09/2013 – 03/2015

Maternity leave and family management (first child, 10 years old)

06/2019 – 09/2020

Maternity leave and family management (second child, 5 years old)

• DZHK funding for Secondary Use Projects: Heart Bank (09/2024- 08/2025)
• DZHK funding for Preclinical Research: Cooperation through Shared Expertise (04/2022- 12/2023)
• DZHK funding Excellence Programme: Promotion of women scientists (05/2022- 12/2023)
• Close The Gap: foundation for publication in revision process (03/2018- 05/2023)

• yDZHK
• Close the Gap network

• Längst N, Adler J, Schweigert O, Kleusberg F, Cruz Santos M, Knauer A, Sausbier M, Zeller T, Ruth P, Lukowski R. Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4). International Journal of Molecular Sciences. 2021; 22(18), 9925. F 5.92
• Schweigert O, Adler J, Längst N, Aïssi D, Duque Escobar J, Tong T, Müller C, Trégouët DA, Lukowski R, Zeller T. CRIP1 expression in monocytes related to hypertension. Clinical Science. 2021 104:276-308. IF 5.22
• Schweigert O, Dewitz C, Möller-Hackbarth K, Trad A, Garbers C, Rose-John S, Scheller J. Soluble T cell immunoglobulin and mucin domain (TIM-) 1 and 4 generated by a disintegrin and metalloproteinase domain-containing proteins (ADAM-) 10 /17 bind to phosphatidylserine. Biochimi Biophys Acta. 2014; 1843(2):275-87. IF 5.05