Dr. rer. nat. Jorge Duque Escobar
- Team leader
- +49 451 – 3101 8312
- Room: 067.000.10.037.00
- jorge.duque@uni-luebeck.de
- ORCID iD: 0000-0002-6215-1555
Our research aims to improve understanding of the multifactorial molecular and immunological mechanisms underlying cardiovascular diseases (CVD), which are highly heterogeneous and affect multiple organs. The focus of our group, ‘Immunoregulation of Cardiometabolic Diseases’, is to explore the complex interactions within the cardiovascular–kidney–metabolic syndrome axis in order to identify new therapeutic targets and biomarkers for clinical use.
Scientific Training
01/2025–present
Team leader – Research group Immunoregulation of Cardiometabolic Diseases, Institute for Cardiogenetics
09/2019–present
Postdoctoral Researcher, University Center of Cardiovascular Science, University Medical Centre Hamburg-Eppendorf
04/2017–08/2019
Postdoctoral Researcher, Institute of Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf
01/2013–03/2017
PhD student at the Institute of Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf. Thesis: Role of the dual leucine zipper kinase (DLK) for the development of type 2 diabetes mellitus
10/2014–07/2016
Graduate Study Program in Molecular Biology at the Center for Molecular Neurobiology Hamburg (ZMNH)
Education
12/2012
Licence as pharmacist, Landesprüfungsamt Hamburg
12/2011–12/2012
Pharmaceutical practical year
10/2007–11/2011
Pharmacy study (state examination), University of Hamburg
Fundings
- Werner Otto Stiftung: “The Role of CRIP1 in the development of hypertensive heart disease: Potential as a biomarker and therapeutic target?” (01.01.2025 – 31.12.2025).
- DZHK Shared Expertise: “Metabolic syndrome as risk factor for CVD: Differential DLK- and CRIP1-dependent gene expression” (01.08.2024 – 31.01.2026).
- DZHK Shared Expertise: “CRIP1: A potential marker to predict COVID-19 severity and its association to hypertension and CVD” (01.04.2023 – 30.09.2024).
- Grant-Postdoctoral Researcher at the University Medical Centre Hamburg-Eppendorf: “Regulation of the beta-cell-damaging kinase DLK By the beta-cell-protective phosphatase calcineurin” – Own position (01.04.2017-31.03.2018)
Roles
- Occupational safety officer
- Deputy for genetic engineering (S1)
Awards
- Werner Otto Stiftung: “The Role of CRIP1 in the development of hypertensive heart disease: Potential as a biomarker and therapeutic target?”(01.01.2025 – 31.12.2025).
- DZHK Shared Expertise: “Metabolic syndrome as risk factor for CVD: Differential DLK- and CRIP1-dependent gene expression” (01.08.2024 – 31.01.2026).
- DZHK Shared Expertise: “CRIP1: A potential marker to predict COVID-19 severity and its association to hypertension and CVD” (01.04.2023 – 30.09.2024).
- Grant-Postdoctoral Researcher at the University Medical Centre Hamburg-Eppendorf: “Regulation of the beta-cell-damaging kinase DLK By the beta-cell-protective phosphatase calcineurin” – Own position (01.04.2017-31.03.2018)
Memberships
- Deutsche Gesellschaft für Kardiologie (DGK)
- Deutsche Pharmazeutische Gesellschaft (DPhG)
- International Society for Heart Research (ISHR-ES)
- Young DZHK
Apothekerkammer Schleswig-Holstein
- Köster KA, Duque Escobar J, Fietkau A, Toledo R, Oetjen E. Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase. Naunyn-schmiedeberg’s Archives of Pharmacology. 2023; 396(6), 1223-1233.
- Duque Escobar J, Kutschenko A, Schröder S, Blume R, Köster KA, Painer C, Lemcke T, Maison W, Oetjen E. Regulation of dual leucine zipper kinase activity through its interaction with calcineurin. Cellular Signalling. 2021; 82, 109953.
- Hannemann J, Cordts K, Seniuk A, Choe CU, Schmidt-Hutten L, Duque Escobar J, Weinberger F, Böger R, Schwedhelm E. Arginine: Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia. Frontiers in Physiology. 2021; 1273.
- Schweigert O, Adler J, Längst N, Aïssi D, Duque Escobar J, Tong T, Müller C, Trégouët DA, Lukowski R, Zeller T. CRIP1 expression in monocytes related to hypertension. Clinical Science. 2021; 135(7), 911-924.
- Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler M, Kluth O, Kehlenbach RH, Miosge N, Oetjen E. Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cellular Signaling. 2016; 28(4), 272-283.