• Genetics of monogenic and complex cardiovascular diseases, especially atherosclerosis and myocardial infarction
  • Genome-wide association (GWA) and NGS studies in large cohorts and extended families
  • Establishment of animal models (mice/zebrafish) to study atherosclerosis
  • Understanding principle molecular mechanisms leading to disease
  • Translation of genetic findings into new diagnostically and therapeutically products
  • Developing treatment strategies for collagen-VI-related dystrophies by mutation-specific knockdown using siRNA/AON and CRISPR/dCas

Since 2013

Director of the Institute for Cardiogenetics (formerly IIEG)

Since 2012

DZHK-professorship (W3) at the University of Lübeck (permanent)

2011-2013

W2-professorship at the University of Lübeck (permanent)

2004-2012

Head of the Molecular Genetic Lab at the Klinik für Innere Medizin II (MKII) des Universitätsklinikums Schleswig-Holstein, Campus Lübeck

2003

Habilitation (Molekulare Kardiologie), University of Regensburg

2000-2003

Head of the Molecular Genetic Lab at the Klinik und Poliklinik für Innere Medizin II der Universitätsklinik Regensburg

1997-2000

Post Doc at the Deutsches Herzzentrum Berlin

1992-1996

PhD (Institut für Humangenetik, University of Bonn, Germany)

1985-1991

Diploma in Biology (University of Köln, Germany)

  • Deutsche Gesellschaft für Kardiologie (DGK)
  • European Society for Cardiology (ESC)
  • Deutsche Gesellschaft für Humangenetik (GfH)
  • Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK)
  • International Society for Heart Research (ISHR), European Section
  • Deutsche Gesellschaft für Muskelkranke (DGM)
  • Zukunft Hanse e.V.
  • ZONTA Club Lübeck
  • Council on Cardiovascular Genomics (ESC)
  • Gesellschaft für Biochemie und Molekularbiologie e.V. (GBM)

2020-ongoing

Contact person for Gesellschaft für Biochemie und Molekularbiologie

2020-ongoing

Member of the “Forschungskommission” University of Lübeck

2020-2023

Deputy Editor, Circulation: Genomics and Precision Medicine

2019-ongoing

Member of the “Stiftungsrat” University of Lübeck

2019-ongoing

Chairwoman of the board of the regional association of the Deutsche Gesellschaft für Muskelkranke e. V.

2019

Senior Guest Editor, Circulation: Genomics and Precision Medicine

2019-ongoing

Third deputy partner site speaker (NCCR)

2019-2022

Coordinator of the BHF/DZHK funded VIAgenomics consortium (Genetic discovery-based targeting of the vascular interface in atherosclerosis)

2018

Highly cited researcher according to Web of Science in category cross-field (2006-2016)

2018-ongoing

COST Action Management Committee member substitute (COST Action CA17103, Delivery of Antisense RNA Therapeutics; DARTER)

2018-ongoing

Member of the steering committee of the Cluster of Excellence “Precision medicine in chronic inflammation” (PMI)

2018-ongoing

Associate Editor, Cardiovascular Research

2015-2019

Specialty Chief Editor, Cardiovascular Genetics and Systems Medicine

2014-2016

Spokeswoman of the project committee of the e:Med program

2013-2017

Co-coordinator of the BMBF funded consortium e:AtheroSysMed (e:Med program)

2013-2017

Co-coordinator of the EU funded consortium CVgenes@target (within FP7)

2012-ongoing

Member of the executive board of the Nordic Center for Cardiovascular Research (NCCR)

2012-2016

Spokeswoman of the SPP „Medizinische Genetik“ at the University of Lübeck

DFG

  • PMI (PI; RTF1, 173,000 €)
  • ProtectMove (1st funding period) (PI; P6, 150,000 €)
  • KFO 303 (PI; Z2, 150,000 €)
  • ProtectMove (2nd funding period) (PI; P9, 214,792 €)

Leducq-Foundation

  • CADgenomics (PI; 2010-2016; 110,000 €)
  • PlaqOmics (PI; 2018-2024; 540,000 €)

DZHK & BHF

  • VIAgenomics (Coordinator; 2019-2024; 376,000 €)
  • DZHK (PI; 2012-2020; 3,742,000 €)

BMBF/e:Med

  • COMMITTMENT (PI; 2019-2022; 200,000 €)

Others (neuromuscular research)

  • Cure CMD (PI; 2020-2022; 50,000 €)
  • Deutsche Gesellschaft für Muskelkranke e. V. (PI; 2019-2021; 18,000 €)

TOTAL FUNDING: 5,700,000

For questions regarding our project management please contact Dr. rer. nat. Nadine Clausen.

  1. Schunkert H, Erdmann J, Samani SNJ. CARDIoGRAM celebrates its 10thAnniversary. Eur Heart J. 2019 Jun 1;40(21):1664-1666. doi:10.1093/eurheartj/ehz347.

  2. Demal TJ, Heise M, Reiz B, Dogra D, Brænne I, Reichenspurner H, Männer J, Aherrahrou Z, Schunkert H, Erdmann J, Abdelilah-Seyfried S. A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A. Sci Rep. 2019 Feb 27;9(1):2959. doi:10.1038/s41598-019-39648-7.

  3. Erdmann J, Kessler T, Munoz Venegas L, Schunkert H. A decade of genome-wide association studies for coronary artery disease: the challenges ahead. Cardiovasc Res. 2018 Jul 15;114(9):1241-1257. doi:10.1093/cvr/cvy084.

  4. Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K,Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferrario M, Ford I, Jukema JW, Kee F, Kuulasmaa K, Nordestgaard BG, Perola M, Saleheen D, Sattar N, Surendran P, Tregouet D, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader D, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Kathiresan S, Deloukas P, Samani NJ, Schunkert H. Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med. 2016 Mar 24;374(12):1134-44. doi:10.1056/NEJMoa1507652.

  5. Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013 Dec 19;504(7480):432-6. doi:10.1038/nature12722.

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