Dr. rer. nat. Stephanie Tennstedt

• Identification of drug targets with a focus on coronary artery disease and myocardial infarction
  
• Prediction of molecular mechanism of proteins by molecular modeling and molecular dynamic simulations
• Design of lead structures by computational methods
• Prediction of functional effects of protein-coding variants
  

2018-ongoing

Senior research fellow

2013-2018

Postdoctoral research fellow

2011-2012

Postdoctoral research fellow, Department of Medicine II, University Medical Center Schleswig-Holstein (Campus Lübeck)

2011

Doctoral degree (Dr. rer. nat.), Faculty of Natural Sciences II, Martin-Luther-University Halle-Wittenberg
Title: “In silico identification and analysis of androgen receptor ago- and antagonists“

2009-2011

Research fellow, Department of Medicine II, University Medical Center Schleswig-Holstein

2009

Scientific training, Department of Cardiovascular Sciences, Glenfield General Hospital (Leicester, UK)
Analysis of gene expression and genotype data

2005-2009

PhD student, Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry Halle (Saale)

2005

Scientific training, Computer Chemistry Center, Friedrich-Alexander University Erlangen-Nürnberg
Structure-activity relationships

2004

Scientific training, Zentaris GmbH Frankfurt am Main
Design of a database for commercial available compounds on basis of MDL-ISIS information management system

2000-2005

School of Bioinformatics (Diploma), Faculty of Natural Sciences III, Martin-Luther-University Halle-Wittenberg
Title of diploma thesis: “Virtual screening of hormone activity of natural products”, Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry Halle (Saale)

–

• Deutsches Zentrum für Herz-Kreislauf Forschung e.V. (DZHK)
  

• Bayer
• Women Excellence Award (DZHK)
  

1. Munz M, Richter GM, Loos BG, Jepsen S, Divaris K, Offenbacher S, Teumer A, Holtfreter B, Kocher T, Bruckmann C, Jockel-Schneider Y, Graetz C, Munoz L, Bhandari A, Tennstedt S, Staufenbiel I, van der Velde N, Uitterlinden AG, de Groot LCPGM, Wellmann J, Berger K, Krone B, Hoffmann P, Laudes M, Lieb W, Franke A, Dommisch H, Erdmann J, Schaefer AS. Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus. Sci Rep. 2018 Sep 12;8(1):13678. doi:10.1038/s41598-018-31980-8.
   
   
2. Lange LM, Tunc S, Tennstedt S, Münchau A, Klein C, Assmann B, Lohmann K. A novel, in-frame KMT2B deletion in a patient with apparently isolated, generalized dystonia. Mov Disord. 2017 Oct;32(10):1495-1497. doi:10.1002/mds.27137.
   
   
3. Müller M, Kessler T, Schunkert H, Erdmann J, Tennstedt S. Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors. Biochem Biophys Res Commun. 2016 Mar 11;471(3):380-5. doi:10.1016/j.bbrc.2016.02.025.
   
   
4. Bürk K, Kaiser FJ, Tennstedt S, Schöls L, Kreuz FR, Wieland T, Strom TM, Büttner T, Hollstein R, Braunholz D, Plaschke J, Gillessen-Kaesbach G, Zühlke C. A novel missense mutation in CACNA1A evaluated by in silico protein modeling is associated with non-episodic spinocerebellar ataxia with slow progression. Eur J Med Genet. 2014 Apr;57(5):207-11. doi:10.1016/j.ejmg.2014.01.005.
   
   
5. Wobst J, von Ameln S, Wolf B, Wierer M, Dang TA, Sager HB, Tennstedt S, Hengstenberg C, Koesling D, Friebe A, Braun SL, Erdmann J, Schunkert H, Kessler T. Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants. Basic Res Cardiol. 2016 Jul;111(4):51. doi:10.1007/s00395-016-0570-5.
   
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