Zc3hc1, the gene encoding for NIPA (Nuclear Interaction Partner of Anaplastic Lymphoma Kinase), has shown a strong association with coronary artery disease/ myocardial infarction (CAD/MI) in genome-wide association studies (GWAS). The functional link between NIPA, a protein that plays a role in cell cycle control, and CAD/MI is so far unknown. Hence, we aim to investigate the role of NIPA in atherosclerosis, a condition leading to MI, using a knockout (KO) mouse model.
