Genetic research, including genome-wide association studies (GWAS), plays an increasingly crucial role in studying the physiology and pathophysiology of cardiovascular disease. Deputy Editor Dr. Carol Ann Remme conducts an interview with authors Prof. Jeanette Erdmann (University of Lübeck, Germany) and Prof. Connie Bezzina (Amsterdam University Medical Center, Netherlands) about their latest Review published in Physiological Reviews by Walsh et al. GWAS focus on identifying genetic variations associated with specific traits, and it is imperative to investigate these variations to comprehend an individual’s susceptibility to particular diseases. Unraveling the genetic foundation of a disease can facilitate the discovery of therapeutic targets for clinical interventions. The experts delve into the application of GWAS in studying rare disorders like Brugada Syndrome, as well as common disorders such as myocardial infarction. The potential applications of GWAS are extensive, ranging from unveiling novel insights into the pathophysiology of cardiovascular disease to potentially developing clinically applicable polygenic risk scores in the future. Tune in to gain a deeper understanding of these topics.