Circulation

Identification of a functional PDE5A variant at the chromosome 4q27 coronary artery disease locus in an extended myocardial infarction family

Dang T, Kessler T, Wobst J, Wierer M, Braenne I, Strom TM, Tennstedt S, Sager H, Meitinger T, Erdmann J, Schunkert H.

Circulation. 2021;144:662–665

https://pubmed.ncbi.nlm.nih.gov/34424768/

Identification of a functional PDE5A variant at the chromosome 4q27 coronary artery disease locus in an extended myocardial infarction family Read More »

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.

Emdin CA, Khera AV, Klarin D, Natarajan P, Zekavat SM, Nomura A, Haas M, Aragam K, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gormley P, Palotie A, Stitziel NO, Gupta N, Danesh J, Saleheen D, Gabriel S, Kathiresan S.

Circulation. 2018 Jan 16;137(3):222-232. doi: 10.1161/CIRCULATIONAHA.117.028021.

https://www.ncbi.nlm.nih.gov/pubmed/28982690

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Read More »

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

Saleheen D, Zhao W, Young R, Nelson CP, Ho W, Ferguson JF, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, Thorleifsson G, Strawbridge RJ, Sinisalo J, Kanoni S, Sedaghat S, Marouli E, Kristiansson K, Hua Zhao J, Scott R, Gauguier D, Shah SH, Smith AV, van Zuydam N, Cox AJ, Willenborg C, Kessler T, Zeng L, Province MA, Ganna A, Lind L, Pedersen NL, White CC, Joensuu A, Edi Kleber M, Hall AS, März W, Salomaa V, O’Donnell C, Ingelsson E, Feitosa MF, Erdmann J, Bowden DW, Palmer CNA, Gudnason V, Faire U, Zalloua P, Wareham N, Thompson JR, Kuulasmaa K, Dedoussis G, Perola M, Dehghan A, Chambers JC, Kooner J, Allayee H, Deloukas P, McPherson R, Stefansson K, Schunkert H, Kathiresan S, Farrall M, Marcel Frossard P, Rader DJ, Samani NJ, Reilly MP.

Circulation. 2017 Jun 13;135(24):2336-2353. doi: 10.1161/CIRCULATIONAHA.116.022069.

https://www.ncbi.nlm.nih.gov/pubmed/28461624

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions Read More »

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus.

Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, von Ameln S, Dang TA, Sager HB, Rumpf PM, Aherrahrou R, Kastrati A, Bjoerkegren JLM, Erdmann J, Lusis AJ, Civelek M, Kaiser FJ, Schunkert H.

Circulation. 2017 May 9. pii: CIRCULATIONAHA.116.024152.doi:10.1161/CIRCULATIONAHA.116.024152.

https://www.ncbi.nlm.nih.gov/pubmed/28487391

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus. Read More »

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W.

Circulation. 2015 Mar 31;131(13):1191-201. doi: 10.1161/CIRCULATIONAHA.114.014072. Epub 2015 Feb 20.

http://www.ncbi.nlm.nih.gov/pubmed/25712208

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1. Read More »

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

Sabater-Lleal, M., Huang, J., Chasman, D., Naitza, S., Dehghan, A., Johnson, A. D., Teumer, A., Reiner, A. P., Folkersen, L., Basu, S., Rudnicka, A. R., Trompet, S., Malarstig, A., Baumert, J., Bis, J. C., Guo, X., Hottenga, J. J., Shin, S. Y., Lopez, L. M., Lahti, J., Tanaka, T., Yanek, L. R., Oudot-Mellakh, T., Wilson, J. F., Navarro, P., Huffman, J. E., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, A. F., Kolcic, I., Polasek, O., Wild, S. H., Campbell, H., Curb, J. D., Wallace, R., Liu, S., Eaton, C. B., Becker, D. M., Becker, L. C., Bandinelli, S., Raikkonen, K., Widen, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G., Harris, S. E., Liewald, D. C., Starr, J. M., Williams, F. M., Grant, P. J., Spector, T. D., Strawbridge, R. J., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, A. G., Franco, O. H., Hofman, A., van Dongen, J., Willemsen, G., Boomsma, D. I., Yao, J., Swords Jenny, N., Haritunians, T., McKnight, B., Lumley, T., Taylor, K. D., Rotter, J. I., Psaty, B. M., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Volzke, H., Kocher, T., Goel, A., Franzosi, M. G., Seedorf, U., Clarke, R., Steri, M., Tarasov, K. V., Sanna, S., Schlessinger, D., Stott, D. J., Sattar, N., Buckley, B. M., Rumley, A., Lowe, G. D., McArdle, W. L., Chen, M. H., Tofler, G. H., Song, J., Boerwinkle, E., Folsom, A. R., et al.

Circulation. 2013 Sep 17;128(12):1310-24. doi: 10.1161/CIRCULATIONAHA.113.002251. Epub 2013 Aug 22.

http://www.ncbi.nlm.nih.gov/pubmed/23969696

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease Read More »

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