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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease

Based on extensive genotypic data from CARDIoGRAM we started a large-scale integrative genomic analyses together with colleagues from USA, Australia, Canada, UK, Singapore, and Germany.

More precisely, we conducted an analysis where we used the information of gene-gene interactions to capture groups of genes that are most likely to increase heart disease risk. In the end, we not only confirmed the importance of several known CAD risk processes such as the metabolism and transport of cholesterol, immune response, and blood coagulation, but also revealed many novel processes such as neuroprotection, cell cycle, and proteolysis that were not previously implicated in CAD. These results published in PLOS Genetics highlight the value of integrating population genetic data with diverse resources that functionally annotate the human genome.

Link: http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004502

e:Med Meeting 2015, October 26-28 in Heidelberg – Registration is open!

On behalf of the e:Med Project Committee we kindly invite you to attend the e:Med Meeting 2015 on Systems Medicine, October 26 – 28 at the DKFZ in Heidelberg.

Please find further information and forms for Registration and Abstract Submission at
http://www.sys-med.de/de/meeting.
Take this chance to meet your colleagues.

There will be no conference fee, but Registration is mandatory.

Abstract submission will be open till September 6, 2015.
The preliminary program comprises five symposia:

1) Epigenetic Methods
2) Genome Editing
3) Cardiovascular Disease
4) Computational Approaches & Clinical Utilities
5) Cancer

Unveil your work to the community by submitting an abstract for talk or poster on the session topics. Six talks will be chosen for presentation in Short Talks. Your Poster will be on display at the poster exposition throughout the conference.
We are looking forward to welcoming you in Heidelberg.
Your e:Med Management Office

Large-scale exome-sequencing identified rare variants which might explain part of the missing heritability for coronary artery disease

In close collaboration with several national and international colleagues members of the IIEG conducted large-scale exome-sequencing in thousands of patients with coronary artery disease and healthy controls. Three papers have been published in the last three months in the prestigious journals NEJM and Nature.

First, we reported that rare mutations disrupting APOC3 function were associated with lower levels of plasma triglycerides and APOC3. Carriers of these mutations were found to have a reduced risk of coronary heart disease.

Second, we described naturally occurring rare loss-of-function mutations in NPC1L1, a drug target for lowering LDL-cholesterol, which were found to be associated with reduced plasma LDL cholesterol levels and a reduced risk of coronary heart disease. Interestingly, human mutations that inactivate a gene encoding a drug target can mimic the action of an inhibitory drug and thus can be used to infer potential effects of that drug.

Third, we identified rare mutations in APOA5 gene which confer a more than two-fold risk for myocardial infarction.

http://www.nejm.org/doi/full/10.1056/NEJMoa1307095

http://www.nejm.org/doi/full/10.1056/NEJMoa1405386

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13917.html

„Universitäres Herzzentrum Lübeck“ (UHZL) newly founded.

Since February 2015 the Medizinische Klinik II (director: Prof. Holger Thiele), the Klinik für Herz- und thorakale Gefäßchirurgie
(director: Prof. Hans-H. Sievers), and the Institut für Integrative und Experimentelle Genomik (IIEG) (director: Prof. Jeanette Erdmann) are united under one roof as the „Universitäres Herzzentrum Lübeck“ (UHZL).

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This new foundation will enable closer collaborations not only between the clinicians but also between the clinicians and the research groups at the IIEG. Such very close collaborations are neccessary for translational research from bench to bedside.
In February 2016 a Symposium will be organized to introduce and celebrate the UHZL.

More infos about the Symposium will follow soon.

Second successful PhD candidate at the IIEG

Congratulations to Redouane who has very successfully defended his PhD thesis in Meknes, Marocco on Wednesday.

His thesis was a joint project between the IIEG and the Moulay Ismail University in Meknes, Marocco. The project was initially funded by the DAAD (Deutscher Akademischer Austauschdienst) within a programme for bi-nationally supervised doctoral degrees (so called sandwich-model) for excellent young students.

The aim of this programme is to promote doctoral degrees at the home university with integrated research phases in Germany. Within this programme Redouane´s doctoral degree was supervised both by Professor Mohieddine MOUMNI and Professor Jeanette ERDMANN from the IIEG as the host Institute.

First PhD thesis defended at the IIEG

Congratulations! Christina defended very sucessfully her PhD thesis about “Genome-wide association studies on coronary artery disease and beyond”.
She is the first PhD student officially affiliated with the IIEG! We are very happy that she will now work as a PostDoc at the IIEG! Hopefully for quite a while!

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